FIGURE 4.

Quantitative systems pharmacology model simulation of evinacumab clinical trial data. Evinacumab clinical data taken from a phase I, single ascending dose study with evinacumab in subjects with hypertriglyceridemia (NCT01749878). ANGIV, angiopoietin‐like protein 3 time course data in intravenous administration; ANGPTL3, angiopoietin‐like protein 3; LPL, lipoprotein lipase; mAB, monoclonal antibody; mABIV, monoclonal antibody time course data in intravenous administration; TG, triglyceride; TGIV, triglyceride time course data in intravenous administration