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CovR/S is required for the CRISPR-mediated adhesion decrease. Adhesion of the WT, ΔCRISPR, ΔcovR/S and ΔCRISPR-covR/S strains to bEnd.3 cells. At 2 h post-infection, cells were washed and lysed for measurement of the number of CFU. Data are presented as the means ± SD of three independent experiments. **P < 0.01 or ***P < 0.001.
