Supplementary Table 3. Biological processes associated with the upregulated genes.

Term	Overlap	p -value	Q-value	Combined Score
kynurenine metabolic process (GO: 0070189)	2/8	8.28E-05	4.69E-02	1342.81
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO: 2001267)	2/9	1.06E-04	4.52E-02	1161.83
indolalkylamine catabolic process (GO: 0046218)	2/9	1.06E-04	4.17E-02	1161.83
tryptophan catabolic process (GO: 0006569)	2/10	1.33E-04	4.84E-02	1020.27
tryptophan metabolic process (GO: 0006568)	2/10	1.33E-04	4.51E-02	1020.27
intestinal absorption (GO: 0050892)	2/13	2.29E-04	7.31E-02	736.76
extracellular matrix disassembly (GO: 0022617)	5/78	2.35E-07	3.99E-04	559.16
B cell chemotaxis (GO: 0035754)	1/6	1.05E-02	7.02E-01	434.35
intermediate filament bundle assembly (GO: 0045110)	1/6	1.05E-02	6.93E-01	434.35
sterol import (GO: 0035376)	1/6	1.05E-02	6.84E-01	434.35
positive regulation of receptor binding (GO: 1900122)	1/6	1.05E-02	6.75E-01	434.35
cellular response to bacterial lipopeptide (GO: 0071221)	1/6	1.05E-02	6.67E-01	434.35
cholesterol import (GO: 0070508)	1/6	1.05E-02	6.59E-01	434.35
positive regulation of keratinocyte migration (GO: 0051549)	1/6	1.05E-02	6.51E-01	434.35
aromatic amino acid family catabolic process (GO: 0009074)	2/20	5.54E-04	1.35E-01	428.46

Enrichment analysis using upregulated genes (Log2 ratio＞ 3, Q＜0.05)