Table 3. Immunopositive area of cells and kynurenine enzymes in aorta.

	A. early lesion ( n = 11)	B. non-aneurysmal advanced lesion ( n = 8)	C. aneurysmal lesion ( n = 11)	p value
				A vs. B	A vs. C	B vs. C
SMA (smooth muscle cell)	30.8 (10.8 - 42.4)	16.2 (12.7 - 25.5)	8.1 (0.2 - 26.6)	0.12	＜0.001	0.36
CD68 (macrophage)	0.01 (0 - 0.08)	1.6 (0.6 - 5.5)	4.9 (0.3 - 11.9)	＜0.01	＜0.0001	1
CD3 (T cell)	0.004 (0 - 0.03)	0.04 (0.01 - 0.2)	0.03 (0 - 0.7)	＜0.01	＜0.01	1
CD20 (B cell)	0.007 (0 - 0.02)	0.01 (0.003 - 0.07)	0.42 (0.001 - 5.1)	1	＜0.05	0.13
CD138 (plasma cell)	0.004 (0.001 - 0.2)	0.019 (0.006 - 0.11)	0.16 (0.01 - 0.53)	0.12	＜0.001	0.29
CD31 (endothelial cell)	1.2 (0.7 - 3.4)	0.8 (0.3 - 2.0)	3.2 (0.9 - 6.3)	0.87	＜0.05	＜0.01
Kynureninase	0.004 (0 - 0.19)	0.4 (0.2 - 3.5)	1.4 (0.004 - 15.1)	＜0.05	＜0.001	1
Kynurenine 3-monooxygenase	0.02 (0 - 0.15)	0.5 (0.2 - 2.7)	0.6 (0 - 4.8)	＜0.01	＜0.01	1

Data are expressed as median and range. SMA (smooth muscle actin) Kruskal-Wallis test with Dunn’s multiple comparison test.