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. 2021 Nov 8;2021:3254488. doi: 10.1155/2021/3254488

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Copyright © 2021 Zhe Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effects of MSCs in promoting the Breg differentiation. (a) The percentages of CD19⁺CD24^hiCD38^hi B cells in periphery B cells from healthy person and ITP patients. (b) The percentages of IL-10-producing CD19⁺ B cells in periphery B cells from healthy person and ITP patients. (c, d) Coculture MSCs with PBMCs at the ratio of 1 : 1 can significantly increase the percentage of CD19⁺CD24^hiCD38^hi B cells and B10 cells. (e) The concentration of IL-10 in medium promoted notably while coculture CD19⁺ B cells with MSC at the ratio of 1 : 1. ^∗P < 0.05.