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SDF-1α pretreatment enhances the property of MSCs in promoting the Breg differentiation. (a, b) 0.1 μg/mL SDF-1α promotes the effects of MSCs on IL-10-producing CD19+ B cells or CD19+CD24hiCD38hi cell differentiation. (c) After being treated with 0.1 μg/mL SDF-1α, MSCs can increase the secretion of IL-10 from B cells further (897 ± 87 pg/mL vs. 706 ± 55 pg/mL). ∗P < 0.05.
