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. 2021 Nov 8;2021:1805147. doi: 10.1155/2021/1805147

Figure 6.

Figure 6

Baicalin reduces pyroptosis in Mtb-infected macrophages by inhibiting PERK/eIF2α activation. (a, c) Western blotting analysis of GSDMD-N expression after IRE1α siRNA in RAW264.7 cells. (b, d) Level of GSDMD-N protein was detected by western blotting after PERK siRNA in RAW264.7 cells. (e, f) Production of IL-β was assessed by ELISA measurement after IRE1α or PERK siRNA, respectively, in RAW264.7 cells. (g) Level of TXNIP protein was analyzed by western blotting after PERK siRNA in RAW264.7 cells. Data are shown as mean ± SD of at least three independent experiments. ∗p < 0.05; ∗∗p < 0.01; NS: nonsignificant.