Table 5.
Viral evasion mechanisms of cGAS-initiated antiviral signaling.
| Signaling molecules | Virus | Virulence factor | Function | Ref |
|---|---|---|---|---|
| cGAMP | Poxviruses, Herpesviruses, Retroviruses | – | Transport | 293,294 |
| VACV | Poxin (B2R) | Cleavage | 295 | |
| STING | DTMUV | NS2B3 | Cleavage | 343 |
| HCV | NS4B | Cleavage | 335 | |
| HBV | Pol | K63-linked ubiquitination | 338 | |
| HSV-1 | VP1-2 | Deubiquitination | 334 | |
| HTLV-1 | Tax | Deubiquitination | 22 | |
| HCMV | IE86 | Proteosomal degradation | 340,341 | |
| HSV-1 | γ1134.5 | Physical interaction | 332 | |
| HSV-1 | ICP27 | Physical interaction | 331 | |
| HSV-1 | UL-46 | Physical interaction | 333 | |
| KSHV | vIRF1 | Physical interaction | 336 | |
| HCMV | UL42 | Physical interaction | 342 | |
| HCMV | UL82 | Physical interaction | 339 | |
| MCMV | M152 | Physical interaction | 337 | |
| TBK1 | MHV-68 | ORF11 | Physical interaction | 345 |
| HSV-1 | γ11–34.5 | Physical interaction | 344 | |
| HSV-1 | UL46 | Physical interaction | 333 | |
| FPV | NS2 | Physical interaction | 346 | |
| HSV-1 | Us11 | Degradation | 196 | |
| IRF3 | BoHV-1 | bICP0 | Proteosomal degradation | 348 |
| VZV | ORF61 | Proteosomal degradation | 351 | |
| KHSV | LANA2 (vIRF3) | Physical interaction | 29 | |
| HSV-1 | VP24 | Physical interaction | 347 | |
| VZV | ORF47 | Physical interaction | 350 | |
| VZV | IE62 | Inhibition of phosphorylation | 349 | |
| VACV | N2 | Inhibition of nuclear translocation | 351 | |
| IRF7 | EBV | LMP1 | K63-linked ubiquitination | 352 |
| KSHV | RTA | Degradation | 354 | |
| KSHV | vIRF4 | Physical interaction | 356 | |
| MDV | VP23 | Physical interaction | 353 | |
| KHSV | vIRF3 | Physical interaction | 355 | |
| KSHV | LANA2 (vIRF3) | Physical interaction | 29 |