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. 2021 Jul 2;34(12):2229–2241. doi: 10.1038/s41379-021-00864-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Association of clinical factors with IT and PT immunophenotypes (upper) and immunophenotypes based on interaction status (lower). Clinical factors have been categorized into two classes based on median. The color scale represents the log10 fold-change between each subgroup such as high vs. low patient age. Only immunophenotypes significant in any correlation (p < 0.05) are shown. B IT and PT immunophenotypes, immune cell interaction, and spatial immunophenotypes have been analyzed with Cox regression analysis (log-rank test) for overall survival. C Kaplan–Meier visualization of overall survival by IT and PT CD45RO+ cytotoxic T cells.