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. 2021 Jun 14;34(12):2109–2121. doi: 10.1038/s41379-021-00847-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Cystic infarct in the left occipital lobe (arrow). B Microscopic examination shows an adjacent Charcot–Bouchard aneurysm (CBA) forming a fibrous ball (arrow) in close proximity to an arteriole with adventitial fibrosis (arrowheads). C Magnified view of the structure highlighted by an arrow in B demonstrates punctate calcifications (arrow). Case 7. D CBA (arrow) in proximity to a microinfarct (arrowhead) in the subcortical white matter. E Magnified view of the CBA (D) shows hyalinization and splitting of the vessel wall with F extensive amyloid deposition (arrow) and scattered senile plaques in the vicinity (arrowheads) highlighted by Aβ40 immunostain. Scale bars: B = 600 µm, C = 200 µm, D = 500 µm, E, F = 100 µm.