Table 3.
Histologic features of Charcot–Bouchard aneurysms (CBAs).
| Feature associated with CBA | Number of cases (%) |
|---|---|
| Multifocality | 5 (42%) |
| Location | |
| Cortex | 6 (50%) |
| Leptomeninges | 3 (25%) |
| Basal ganglia | 5 (42%) |
| Hyalinization/fibrosis | 10 (83%) |
| Fibrinoid necrosis | 1 (8%) |
| Large hemorrhage | 0 (0%) |
| Microhemorrhage | 2 (17%) |
| Perivascular hemosiderin | 2 (17%) |
| Perivascular macrophages (HE, CD163 and/or CD206) | 10 (83%) |
| Macrophages within wall or fibrosis (HE, CD163) | 6 (50%) |
| Pericytes (PDGFRβ) | 0 out of 7b |
| Calcifications | 2 (17%) |
| CAAa | 3 out of 5b |
| Features of background brain and other vessels | |
|---|---|
| Infarct(s) in same section as CBA | 3 (25%) |
| Infarct(s) anywhere in brain | 7 (58%) |
| Large hemorrhage or microhemorrhage in same section as CBA | 0 (0%) |
| Large hemorrhage or microhemorrhage anywhere in brain | 4 (33%) |
| Perivascular hemosiderin score in same section as CBAc | |
| ≥3 | 8 (67%) |
| <3 | 3 (25%) |
| Arteriolosclerosis score in same section as CBAc | |
| ≥3 | 3 (25%) |
| <3 | 9 (75%) |
| Atherosclerosis score | |
| Severe | 5 (42%) |
| Mild to moderate | 7 (58%) |
| CAA in same section as CBAa | 6 out of 7 |
| CAA anywhere in brain | 9 (75%) |
| Moderate to severe | 6 (50%) |
| Mild | 3 (25%) |
| Capillary CAA present | 6 (50%) |
| Calcification in same section as CBA | 2 (17%) |
| Calcification anywhere in brain | 3 (25%) |
aCortical/leptomeningeal locations only, in subjects with CAA.
bOut of cases in which CBAs still present in the deeper stained sections.
cScoring according to the VCING criteria [37].