Figure 1.

Genetic approaches to manipulate the expression of AMPA receptors in OPCs. Synaptic vesicles containing glutamate (green dots) will be released upon the arrival of action potentials. The release of glutamate will activate post-synaptic AMPA receptors and evoke a post-synaptic current (dark gray traces). (A) Genetically silencing all AMPA receptor subunits will diminish AMPA receptor-mediated postsynaptic currents. (B) Silencing the GluA2 subunit alone will increase Ca²⁺ permeability through AMPA receptors. (C) Expressing the GluA2-containing AMPA receptor will block the Ca²⁺ entry through AMPA receptors. OPCs, oligodendrocyte precursor cells.