Table 3.
Ovarian stimulation variables and ICSI results of HBV-positive and HBV-negative groups.
|
HBV group
(n = 77) |
Control group
(n = 154) |
P-value | |
|---|---|---|---|
| Female age (years) | 33.5 ± 5.0 | 33.5 ± 4.6 | 0.969a |
| Female BMI (kg/m2) | 23.2 ± 3.0 | 22.6 ± 2.8 | 0.172a |
| Duration of subfertility (years) | 5.9 ± 4.0 | 5.8 ± 3.7 | 0.794a |
| Primary infertility (n, %) | 55/77 (71.4%) | 96/154 (62.3%) | 0.171b |
| Causes of subfertility (n, %) | |||
| Male factor | 56/77 (72.7%) | 111/154 (72.0%) | 0.917b |
| Tubal blockage | 22/77 (28.5%) | 47/154 (30.5%) | 0.760b |
| Ovulation failure | 14/77 (18.1%) | 26/154 (16.8%) | 0.805b |
| Endometriosis | 4/77 (0.05%) | 6/154 (0.03%) | 0.647b |
| Unexplained | 5/77 (0.06%) | 10/154 (0.06%) | 1.000b |
| Total dose of gonadotropin used (IU) | 2,021.5 ± 802.5 | 2,054.0 ± 737.0 | 0.766a |
| Duration of gonadotropin stimulation (d) | 10.2 ± 3.2 | 9.9 ± 2.5 | 0.121c |
| Serum E2 level on the day of hCG injection (pg/ml) | 2,747.2 ± 1,278.0 | 2,539.6 ± 1,285.5 | 0.247a |
| Serum P level on the day of hCG injection (ng/ml) | 0.7 ± 0.3 | 0.7 ± 0.5 | 0.331c |
| Endometrial thickness on the day of hCG injection (mm) | 10.2 ± 1.7 | 9.9 ± 1.8 | 0.162a |
| 2PN fertilization rate (%) | 416/512 (81.2%) | 814/1,020 (79.8%) | 0.502b |
| High-grade embryo rate (%) | 203/353 (57.5%) | 398/675 (58.9%) | 0.652b |
| Implantation rate (%) | 48/143 (33.5%) | 97/296 (32.7%) | 0.867b |
| Clinical pregnancy rate (n, %) | 38/77 (49.3%) | 77/154 (50.0%) | 0.925b |
| Abortion rate (n, %) | 8/38 (21.0%) | 13/77(16.8%) | 0.586b |
Values are presented as mean ± standard deviation.
P-values were obtained using aTwo-sided t-test, bChi-squared test, or cWilcoxon rank sum test.
HBV, Hepatitis B virus; BMI, body mass index; E2, estradiol; P, progesterone; hCG, human chorionic gonadotrophin; 2PN, two-pronuclear.