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. 2021 Nov 2;8:708052. doi: 10.3389/fmolb.2021.708052

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Copyright © 2021 He, Gu, Zou, Yang, Zhang, Ding and Teng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multi-ROC curves assessing discriminant capabilities of the significantly disturbed metabolic pathways in the pCR patients compared with the pSD patients. The AUC values shown in brackets are used to evaluate the performances of various biomarker models: (A) glycine, serine, and threonine metabolism; (B) valine, leucine, and isoleucine biosynthesis; (C) alanine, aspartate, and glutamate metabolism; (D) glutamine and glutamate metabolism; (E) arginine biosynthesis; (F) histidine metabolism.