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. 2021 Nov 2;8:704910. doi: 10.3389/fmolb.2021.704910

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Copyright © 2021 Wang, Li, Wen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment and validation of a 46-genes prognostic model for KIRP patient’s OS. (A) Differences in risk scores among all patients with different smoking histories. (B) Differences in risk scores among patients with different stages. (C) KM curves showed a difference in OS among KIRP patients with different risk scores. (D) Univariate and (E) multivariate Cox regression analyses were applied to analyze the effects of risk scores on OS along with other clinical features. The ROC curves of the ability of the smoking-related model and other clinical features to predict KIRP patient’s (F) 1-, (G) 3- and (H) 5-years OS. (I) A nomogram was constructed by combining the smoking-related model with age, gender, and stage to predict 1-, 3- and 5-years OS of KIRP. Calibration diagrams were applied to assess the consistency of nomogram prediction of KIRP’s (J) 1-, (K) 3- and (L) 5-years OS with real results.