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. 2021 Aug 14;100(12):2943–2956. doi: 10.1007/s00277-021-04615-8

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© The Author(s) 2021, corrected publication 2022

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Fig. 3 — Gene ontology (GO) analysis in MPN patient- vs. HC-derived CD34⁺ cells. GO terms analysis of biological processes (green), and cellular components (yellow), and molecular functions (red). Graphs show the 10 most significantly enriched ontologies with over-representation of GO terms in up- (left) or downregulated (right) genes vs. HC, ranked by adj. p-value. GO terms were restricted to terms with less than 500 genes. A list of all deregulated GO terms including gene numbers and p-values is provided in Supplemental Table 5. ET, essential thrombocythemia; HC, healthy controls; PMF, primary myelofibrosis; PV, polycythemia vera; SMF, secondary myelofibrosis