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. 2021 Sep 22;394(12):2363–2379. doi: 10.1007/s00210-021-02149-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Effects of runcaciguat in ZDF rats treated with either vehicle or runcaciguat (140 ppm) on urinary and plasma biomarkers. Gene expression of A NGAL, B KIM-1, and C OPN in the kidney at study end (42 weeks of treatment). Plasma levels of D OPN at study end and E urinary OPN levels at baseline (0) and after 12, 21, and 30 weeks of treatment expressed as ratio to urinary creatinine. Data are mean ± SEM; significant changes were determined by one-way ANOVA followed by Dunnett’s multiple comparison or t-test with */**/*** for p < 0.05/0.01/0.001