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. 2021 Sep 22;394(12):2363–2379. doi: 10.1007/s00210-021-02149-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Effects of runcaciguat on urinary and plasma biomarkers in L-NAME-supplemented RenTG rats treated with either vehicle or runcaciguat (0.3, 1, or 3 mg/kg/bid) at study end (8 weeks of treatment). Urinary levels of A NGAL, B OPN, and C KIM-1 and plasma levels of D NGAL and E OPN. Data are mean ± SEM; N = 8–13 per group after completion of the study. Significant changes were determined by one-way ANOVA followed by Dunnett’s multiple comparison with * for P < 0.05