Table 1.

Effects of runcaciguat in ANG-supplemented SD rats on body weight (BW), kidney weight (KW), and KW to BW ratios at study end (2 weeks of treatment). ANG-SD rats were treated with either vehicle or runcaciguat (0.3, 1, and 3 mg/kg/bid). Data are mean ± SEM; N = 12/group. Significant changes were determined by one-way ANOVA followed by multiple comparison with */**/***/**** for P < 0.05/0.01/0.002/0.001/0.0001 compared to control rats

Treatment groups	BW [g]	KW [g]	KW/BW [g/kg]
Vehicle	268,5 ± 7	1.069 ± 0.021***	4.0 ±  0.1
Runcaciguat 0.3 mg/kg/bid	269 ± 5	1.067 ± 0.034***	4.0 ± 0.1
Runcaciguat 1 mg/kg/bid	266 ± 6	1.020 ± 0.039***	3.8 ± 0.1 P = 0.051
Runcaciguat 3 mg/kg/bid	270 ± 7	1.053 ± 0.037****	3.9 ± 0.1