Table 2.

Effects of runcaciguat in L-NAME-supplemented RenTG rats on body weight (BW) and organ weight/BW ratios from heart (HW), right and left ventricle (RVW, LVW), and kidney (KW) at study end (8 weeks of treatment). L-NAME-RenTG rats were treated with either vehicle or runcaciguat (0.3, 1, or 3 mg/kg/bid). Data are mean ± SEM; N = 8–13/group. Significant changes were determined by one-way ANOVA followed by multiple comparison with */**/***/**** for P < 0.05/0.01/0.002/0.001/0.0001

Treatment groups	BW [g]	HW/BW [g/kg]	LVW/BW [g/kg]	RVW/BW [g/kg]	KW/BW [g/kg]
Vehicle	390 ± 12	4.02 ± 0.12	3.40 ± 0.11	0.62 ± 0.03	7.48 ± 0.06
Runcaciguat 1 mg/kg/bid	455 ± 16*	3.47 ± 0.09***	2.94 ± 0.07***	0.53 ± 0.03*	7.12 ± 0.15
Runcaciguat 3 mg/kg/bid	427 ± 17 P = 0.050	3.55 ± 0.09***	3.00 ± 0.07**	0.54 ± 0.02 P = 0.051	7.13 ± 0.11 P = 0.051
Runcaciguat 10 mg/kg/bid	441 ± 13*	3.38 ± 0.06****	2.83 ± 0.05****	0.55 ± 0.01	7.17 ± 0.09