. 2021 Sep 22;394(12):2363–2379. doi: 10.1007/s00210-021-02149-4

Table 3.

Effects of runcaciguat in ZDF rats on body weight (BW) and organ weight/BW ratios from heart (HW), right and left ventricle (RVW, LVW), and kidney (KW) at study end (42 weeks of treatment). ZDF rats were treated with either vehicle or runcaciguat (140 ppm). Data were expressed as mean ± SEM; N = 14–15/group. Significant changes were determined with unpaired t-test with * for p < 0.05

Treatment groups	BW [g]	HW/BW [g/kg]	LVW/BW [g/kg]	RVW/BW [g/kg]	KW/BW [g/kg]
Vehicle	324 ± 21.7	4.37 ± 0.32	3.68 ± 0.27	0.70 ± 0.06	6.99 ± 0.46
Runcaciguat 140 ppm	363 ± 27.8 p = 0.161	3.875 ± 0.26 p = 0.120	3.12 ± 0.17*	0.76 ± 0.10 p = 0.310	6.55 ± 0.67 p = 0.318

Treatment groups

BW [g]

HW/BW [g/kg]

LVW/BW [g/kg]

RVW/BW [g/kg]

KW/BW [g/kg]

Vehicle

324 ± 21.7

4.37 ± 0.32

3.68 ± 0.27

0.70 ± 0.06

6.99 ± 0.46

Runcaciguat 140 ppm

363 ± 27.8

p = 0.161

3.875 ± 0.26

p = 0.120

3.12 ± 0.17*

0.76 ± 0.10

p = 0.310

6.55 ± 0.67

p = 0.318