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. 2021 Nov 15;12:6565. doi: 10.1038/s41467-021-26851-2

Fig. 10. PQBP1 depletion in microglia recovers memory functions impaired by Tau.

Fig. 10

a Memory dysfunction after injection of various species of tau in non-polymerized or polymerized state was evaluated by Y-maze test and Morris water maze test. Protocol from injection to memory function tests in various conditions is shown in Fig. 6a. Y-maze test: N number in each group is indicated in Source data. In Morris water maze test, values in each group are presented as mean ± SEM; N = 6 mice/group. #P < 0.05, ##P < 0.01, ###P < 0.001 in Dunnett’s test. Box plots show the median, quartiles. and whiskers that represent data outside the 25th to 75th percentile range. b PQBP1-depndent and PQBP1-independent pathways mediating microglia activation to neuronal cell death or neuronal cell death to microglia activation. Different types of tau species trigger distinct pathways.