Table 3.

Change and change difference of accommodative amplitude and pupil diameter in three groups over 2-year.

Variables	Mean (95% CI)
	0.02% atropine			0.01% atropine			Control group	Change difference between 0.02% and 0.01% atropine
	0–4 months change	4–24 months change	0–24 months change	0–4 months change	4–24 months change	0–24 months change	0–24 months change	0–4 months	P value	4–24 months	P value	0–24 months	P value
Accommodative amplitude (diopters/month)	− 0.71* (− 1.01 to − 0.41)	0.01 (− 0.01 to 0.03)	− 0.11* (− 0.15 to − 0.06)	− 0.57* (− 2.67 to − 1.95)	0.01 (− 0.02 to 0.04)	− 0.09* (− 2.7 to − 0.1)	− 0.03 (− 0.07 to 0.01)	− 0.13 (− 0.32 to 0.06)	0.84	0 (− 0.02 to 0.02)	0.75	− 0.02 (− 0.03 to 0.01)	0.69
Pupil diameter (mm/month)	0.24* (0.17 to 0.31)	0.002 (− 0.001 to 0.005)	0.04* (0.02 to 0.06)	0.24* (0.16 to 0.32)	0.001 (− 0.001 to 0.003)	0.04* (0.03 to 0.05)	0.001 (− 0.001 to 0.003)	0.001 (− 0.002 to 0.004)	0.89	0.001 (− 0.003 to 0.005)	0.91	0 (0 to 0.001)	0.76

CI: confidence interval. Change: represents the slope of accommodative amplitude and pupil diameter over time for three groups.

Change difference: represents the difference in slope of accommodative amplitude (D/month) and pupil diameter (mm/month) over time between each two groups.

A generalized additive mixed model was used to estimate the longitudinal trend.

*Represents: changes were significantly different.