Table 2.

Impact of impaired calcineurin-NFAT signaling on neutrophil functions during infection.

Pathogen	Experimental model/Patient’s cohort	Used inhibitor	Effect on neutrophil function	References
Aspergillus fumigatus	Patients after HSCT		Impaired A.f. hyphae growth inhibition	(15)
Aspergillus fumigatus	C57BL/6 WT mice and Rag2-/- mice	FK506	Impaired neutrophil recruitment and fungal killing	(66)
Aspergillus fumigatus	zebrafish	FK506	Reduced neutrophil recruitment (and increased mortality)	(66)
Aspergillus fumigatus	Mice (BALB/c and C57BL/6)	FK506 with hydrocortisone	Unspecific effect leading to increased mice/host mortality	(75)
Escherichia coli (UPEC)	Mice	CsA	Impaired CXCL2 and CXCL1 production, decreased neutrophil recruitment/migration and phagocytic killing of UPEC	(76)
Escherichia coli (UPEC)	Renal transplant recipients	CsA	Defective NOD-1 mediated bacterial phagocytosis by neutrophils	(76)
Candida albicans	Mice (WT and Rag2-/-)	CsA	Decreased ex vivo killing of C. albicans by neutrophils leading to increased mortality	(68)
M1 protein from Streptococcus pyogenes	Mice	A-285222	Reduced neutrophil infiltration in lung	(77)

CsA, Cyclosporine A; FK506, Tacrolimus; UPEC, uropathogenic Escherichia coli.