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. 2021 Nov 2;9:744560. doi: 10.3389/fbioe.2021.744560

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Copyright © 2021 Corti, Colombo, Migliavacca, Rodriguez Matas, Casarin and Chiastra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Examples of lattice-free and lattice-based agent-based model (ABM) at the cell scale. (A) Lattice-free ABM. (B) Lattice-based ABM with one lattice site corresponding to a single agent, i.e., cell or extracellular matrix (ECM). (C) Lattice-based ABM with multiple agents (cells and ECM) at one lattice site. (D) Lattice-based ABM with agents (cells and ECM) occupying more than one lattice site. The lattice-based ABMs shown in (B–D) are implemented on a hexagonal lattice, as in Corti et al. (2020).