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. 2021 Nov 2;9:744560. doi: 10.3389/fbioe.2021.744560

FIGURE 4.

FIGURE 4

Schematic representation of a general multiscale framework of vascular adaptation. The main simulated events at the different spatio-temporal scales are: 1) structural mechanics and fluid dynamics, 2) cellular activity and 3) molecular transport. The modules receive proper inputs (red arrows) and generate suitable outputs (green arrows).