Table 1.
Participants characteristics.
| Factor | REVEAL-HBV | ||
|---|---|---|---|
| HCC cases | Cirrhosis cases | Controls | |
| Total N | 175 | 117 | 165 |
| % Male | 80.6% | 78.6% | 81.2% |
| Median age at sample date (range) | 51 (30–67) | 46 (32–69) | 51 (30–66) |
| Median year of serum collection (range) | 1993 (1992–1997) | 1993 (1992–1997) | 1993 (1992–1998) |
| Median years of follow-up (range)* | 15.4 (1.7–23.6) | 19.8 (5.3–23.7) | 19.9 (5.5–22.4) |
| Median BMI (range) | 24.4 (17.0–37.7) | 23.8 (16.4–32.6) | 23.4 (17.2–33.4) |
| ALT, N (%) | |||
| < 15 | 65 (37.1) | 48 (41.0) | 98 (59.4) |
| 15–44 | 83 (47.4) | 60 (51.3) | 59 (35.8) |
| ≥ 45 | 27 (15.4) | 9 (7.7) | 8 (4.8) |
| Smoking† | |||
| No | 103 (58.9) | 71 (60.7) | 108 (65.5) |
| Yes | 71 (40.6) | 46 (39.3) | 57 (34.5) |
| Alcohol drinking† | |||
| No | 140 (80.0) | 104 (88.9) | 138 (83.6) |
| Yes | 34 (19.4) | 13 (11.1) | 26 (15.8) |
| Family history of HCC | |||
| No | 158 (90.3) | 112 (95.7) | 151 (91.5) |
| Yes | 17 (9.7) | 5 (4.3) | 14 (8.5) |
| HBeAg positive at baseline | |||
| No | 99 (56.6) | 91 (77.8) | 146 (88.5) |
| Yes | 76 (43.4) | 26 (22.2) | 19 (11.5) |
| Median HBV DNA level (copies/ml) at sample date | 1,938,060 | 141,426 | 45,920 |
*Time from entry to HCC diagnosis, death, or end of study (December 31, 2011), whichever came first.
†Numbers do not add to total due to missing values.