Fig. 3. Autoinhibitory loop and oncogenic mutations.

Residues whose substitution resulted in increased H3K36 methyltransferase activity are indicated with underlined labels. The autoinhibitory loop is colored orange. A water molecule mediating the interaction with T1150 and D1182 in the H3-free form is shown as a red sphere. a Structure of the H3-free NSD2 (PDB ID 5LSU)¹⁸. b A schematic illustration of (a). c Structure of the NSD2-nucleosome complex. d A schematic illustration of (c).