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Schematic depicting activation of cGAS/STING pathway by PARP inhibition, leading to downstream type 1 interferon production resulting in a direct immunosuppressive effect by the cancer cell, as well as increased natural killer (NK) cell and CD8 cytotoxic T cell activity causing direct anti-tumour killing. IFN interferon, TBK-1 tank-binding kinase 1, interferon regulatory factor 3, APC antigen-presenting cell
