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. 2021 Nov 15;11:22242. doi: 10.1038/s41598-021-01473-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative clinical photographs showing the extent of local disease at baseline and before the indicated cycles of T-VEC treatment. Each row corresponds to a single patient. Local reactions after treatment initiation included (A) skin scabbing, flattening of lesions, edema, skin thickening, and hyperpigmentation; (B) hyperpigmentation, skin thickening, and new lesions; (C) increase in tumor burden/new lesions, erythema, and necrosis in tumor; and (D) edema, erythema, skin scabbing, and hyperpigmentation. *Patient did not proceed with therapy.