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. 2021 Nov 2;14:767842. doi: 10.3389/fnmol.2021.767842

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Copyright © 2021 Tabuchi and Ihara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model by which MKL/MRTF and its isoforms regulate neuronal morphology and transcription. MKL/MRTF is localized in dendrites and dendritic spines. MKL/MRTF is an actin-binding protein and SRF cofactor. MKL/MRTF might act locally in dendrites and dendritic spines as well as bind to SRF to regulate IEGs or cytoskeletal genes in the nucleus to modulate spine maturation and dendritic complexity. In addition, the generation of multiple MKL/MRTF isoforms might fine-tune neuronal morphology and gene transcription in neurons. The overexpression studies of MKL/MRTF isoforms in terms of dendritic complexity are summarized on the right side. ± indicates no change; a down arrow indicates a decrease in dendritic complexity, and an up arrow indicates an increase in dendritic complexity. N.T. indicates not tested. IEG, immediate early gene.