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. 2021 Nov 15;11:22271. doi: 10.1038/s41598-021-01162-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Placement of regions of interest (ROIs). (A) Placement of circular ROIs for the white matter (WM) of the left frontal lobe, WM of the left internal capsule, and gray matter (GM) of the left-sided thalamus (using axial slices at the level of the basal ganglia/third ventricle); (B) Placement of circular ROIs within ischemic demarcation (adjacent to the left lateral ventricle) and within a homologue, unaffected area of the contralateral hemisphere (using axial slices at the level of ischemic demarcation).