FIGURE 5.

Basic fibroblast growth factor and TGF-β expression was upregulated by PBM and inhibited by A1 astrocyte activation. (A) The mRNA levels of proinflammatory factors and neurotrophic factors in each group at 3 dpi. n = 5 individuals per group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, the SCI + vehicle group vs. the sham control group; ^#p < 0.05, ns, not significant, the SCI + PBM group vs. the SCI + vehicle group. (B,C) The levels of bFGF and TGF-β in the indicated medium were measured by ELISA. The experiments were independently repeated four times. *p < 0.05, **p < 0.01, ***p < 0.001. (D,F) The effect of different concentrations of bFGF and TGF-β on reactive astrocyte-related transcript levels in resting astrocytes. (E,G) The effects of different concentrations of bFGF and TGF-β on reactive astrocyte-related transcript levels in A1 astrocytes 24 h after induction. The data are shown as the fold change compared to the control group, as determined by RT-PCR. The experiments were independently repeated three times.