Figure 2.

Temporal trajectories of Sarnat score–stratified serum biomarkers. Temporal trajectories of VEGF (A), tau (B), GFAP (C), and IL-10 (D) levels during the first 7 days of life (DOL 0–6) stratified by Sarnat score (1, white; 2, gray, and 3, black) are shown. Two specimens were collected during first 24 h of life (DOL 0), the first sample obtained after admission and the one collected in the second 12 h of life. Data are represented as box-and-whiskers plot, where the box represents the IQR limited by the 25th and 75th percentiles, with solid line inside the box representing the median. Whiskers are limited by the last data point sitting within 1.5 times the IQR, whereas outliers are represented as circles beyond the boundaries of the whiskers. The biomarker level in a 10-base log scale is shown in the y axis. Time in hours and DOL for all panels are depicted in the bottom of the figure. TH exposure occurred for 72 h upon admission to the NICU (for simplification DOL 0–2). *p < 0.05 (KW analysis of variance with Dunn Bonferroni post-hoc analysis). DOL, day of life; GFAP, glial fibrillary acidic protein; IL, interleukin; TH, therapeutic hypothermia; VEGF, vascular endothelial growth factor.