Table 2.
Longitudinal biomarker levels.
| DOL | Median (IQR) | N | DOL | Median (IQR) | N | ||||
|---|---|---|---|---|---|---|---|---|---|
| BDNF (pg/ml) | 0 (Admission) | 1,365.3 (630.9, 2,318.5) | 85 | p = 0.02 | IL-6 (pg/ml) | 0 (Admission) | 16.4 (7.54, 54.5) | 85 | p < 0.001 |
| 0 | 1,308.2 (799.2, 1,883.1) | 125 | 0 | 21.8 (11.3, 49.5) | 126 | ||||
| 1 | 1,027.8 (600.4, 1,499.5) | 131 | 1 | 16.0 (10.1, 30.1) | 131 | ||||
| 2 | 798.2 (513.6, 1,431.9) | 124 | 2 | 9.15 (5.63, 16.5) | 125 | ||||
| 3 | 924.8 (546.2, 1,509.4) | 124 | 3 | 5.09 (3.23, 10.3) | 124 | ||||
| 4 | 1,018.5 (662.9, 1,657.6) | 85 | 4 | 3.35 (1.68, 5.58) | 86 | ||||
| 5 | 1,360.7 (873.3, 2,177.5) | 78 | 5 | 2.96 (1.61, 6.28) | 79 | ||||
| 6 | 1,529.7 (803.6, 2,808.2) | 66 | 6 | 3.05 (1.59, 8.60) | 66 | ||||
| VEGF (pg/ml) | 0 (Admission) | 36.2 (0.164, 165.4) | 83 | p = 0.19 | IL-8 (pg/ml) | 0 (Admission) | 83.1 (37.7, 248.8) | 80 | p < 0.001 |
| 0 | 114.6 (36.1, 214.7) | 123 | 0 | 102.9 (45, 211.4) | 109 | ||||
| 1 | 130.5 (71.9, 254.9) | 130 | 1 | 72.9 (47.8, 155.3) | 114 | ||||
| 2 | 135.9 (78.2, 232.9) | 124 | 2 | 60.3 (39.9, 96.5) | 104 | ||||
| 3 | 141.6 (79.6, 229.7) | 123 | 3 | 53.2 (35.1, 85.1) | 107 | ||||
| 4 | 151.5 (85.7, 254.8) | 86 | 4 | 55.3 (33.6, 94.1) | 76 | ||||
| 5 | 138.0 (77.5, 232.0) | 79 | 5 | 45.7 (32.4, 103) | 70 | ||||
| 6 | 133.7 (80.4, 234.3) | 66 | 6 | 51.5 (29.6, 126.1) | 60 | ||||
| Tau (pg/ml) | 0 (Admission) | 185.3 (79.9, 386.8) | 85 | p = 0.19 | IL-10 (pg/ml) | 0 (Admission) | 8.30 (2.67, 43.18) | 80 | p < 0.001 |
| 0 | 193.5 (84.3, 429.5) | 126 | 0 | 2.72 (1.16, 8.38) | 109 | ||||
| 1 | 179.9 (62.7, 452.8) | 128 | 1 | 1.28 (0.56, 2.96) | 114 | ||||
| 2 | 178.0 (81.4, 536.6) | 121 | 2 | 0.763 (0.29, 1.27) | 104 | ||||
| 3 | 236.7 (112.3, 566.8) | 128 | 3 | 0.456 (0.06, 0.90) | 107 | ||||
| 4 | 267.9 (123.2, 598.8) | 86 | 4 | 0.260 (0.06, 0.70) | 76 | ||||
| 5 | 300.7 (147.6, 790.2) | 74 | 5 | 0.312 (0.06, 0.97) | 70 | ||||
| 6 | 206.5 (95.9, 482.7) | 65 | 6 | 0.518 (0.06, 1.05) | 60 | ||||
| GFAP (ng/ml) | 0 (Admission) | 0.203 (0.082, 1.079) | 89 | p = 0.06 | (IL-6*IL-8) /IL-10 Index | 0 (Admission) | 177.4 (64.3, 602.7) | 80 | p = 0.99 |
| 0 | 0.302 (0.071, 1.33) | 130 | 0 | 984.9 (354.4, 2,459.3) | 109 | ||||
| 1 | 0.287 (0.072, 1.46) | 134 | 1 | 1,078.9 (437.9, 5,578.7) | 114 | ||||
| 2 | 0.353 (0.092, 1.61) | 130 | 2 | 872.0 (308.3, 4,264.2) | 104 | ||||
| 3 | 0.371 (0.105, 1.55) | 133 | 3 | 1,183.7 (322.1, 3,437) | 107 | ||||
| 4 | 0.581 (0.111, 2.00) | 91 | 4 | 860.8 (288.7, 3,028.3) | 76 | ||||
| 5 | 0.769 (0.112, 2.58) | 78 | 5 | 771.1 (190.9, 3,258.4) | 70 | ||||
| 6 | 0.712 (0.071, 2.20) | 66 | 6 | 771 (157.7, 2,392.6) | 60 |
Analysis by linear trend of medians for the overall trajectory. Machado and Santos Silva (35). BDNF, brain-derived neurotrophic factor; DOL, day of life; GFAP, glial fibrillary acidic protein; IQR, interquartile range; IL, interleukin; VEGF, vascular endothelial growth factor.
Bold represent p-values < 0.05.