Table 4B.
Correlation between indicators of HI severity and cytokines during the first week of life.
| Apgar 5 min | Worse pH | Worse BE | NRBCs | Lactate | Sarnat score | PI score | ||
|---|---|---|---|---|---|---|---|---|
| (n = 172) | (n = 178) | (n = 177) | (n = 176) | (n = 109) | (n = 178) | (n = 178) | ||
| DOL | ρ | ρ | ρ | ρ | Rho | ρ | ρ | |
| ( p -value) | ( p -value) | ( p -value) | ( p -value) | ( p -value) | ( p -value) | ( p -value) | ||
| IL-6 | 0 (A) | −0.19 (0.09) | −0.11 (0.31) | −0.18 (0.11) | 0.40 (<0.01) | 0.25 (0.05) | 0.21 (0.06) | 0.17 (0.13) |
| 0 | −0.15 (0.11) | −0.11 (0.24) | −0.09 (0.35) | 0.17 (0.06) | 0.07 (0.53) | 0.06 (0.53) | 0.04 (0.69) | |
| 1 | 0.10 (0.28) | −0.18 (0.05) | −0.19 (0.03) | 0.06 (0.54) | 0.08 (0.46) | −0.01 (0.95) | 0.09 (0.34) | |
| 2 | 0.01 (0.88) | −0.15 (0.10) | −0.16 (0.08) | 0.28 (<0.01) | 0.19 (0.09) | 0.03 (0.76) | 0.03 (0.74) | |
| 3 | 0.001 (0.99) | −0.25 (<0.01) | −0.12 (0.19) | 0.18 (0.05) | 0.10 (0.37) | 0.07 (0.47) | 0.10 (0.27) | |
| 4 | −0.02 (0.86) | −0.15 (0.17) | −0.05 (0.63) | 0.32 (<0.01) | 0.35 (<0.01) | −0.16 (0.14) | 0.09 (0.42) | |
| 5 | 0.01 (0.91) | −0.07 (0.56) | −0.03 (0.80) | 0.40 (<0.01) | 0.24 (0.08) | −0.01 (0.95) | −0.01 (0.96) | |
| 6 | −0.05 (0.73) | −0.16 (0.21) | −0.03 (0.81) | 0.23 (0.07) | 0.26 (0.11) | 0.12 (0.36) | 0.15 (0.25) | |
| IL−8 | 0 (A) | −0.22 (0.06) | −0.03 (0.81) | −0.26 (0.02) | 0.52 (<0.01) | 0.34 (<0.01) | 0.15 (0.18) | 0.14 (0.21) |
| 0 | −0.23 (0.02) | −0.07 (0.49) | −0.18 (0.07) | 0.38 (<0.01) | 0.26 (0.03) | 0.22 (0.03) | 0.22 (0.02) | |
| 1 | 0.04 (0.71) | −0.21 (0.03) | −0.13 (0.19) | 0.24 (0.01) | 0.33 (<0.01) | 0.05 (0.62) | 0.09 (0.35) | |
| 2 | −0.11 (0.29) | −0.11 (0.27) | −0.11 (0.29) | 0.26 (<0.01) | 0.33 (<0.01) | −0.03 (0.76) | 0.01 (0.92) | |
| 3 | −0.01 (0.92) | −0.05 (0.60) | −0.02 (0.82) | 0.04 (0.67) | 0.14 (0.22) | −0.05 (0.63) | −0.03 (0.79) | |
| 4 | −0.08 (0.50) | −0.02 (0.87) | 0.09 (0.45) | 0.04 (0.72) | 0.004 (0.98) | −0.17 (0.14) | −0.09 (0.45) | |
| 5 | −0.09 (0.47) | −0.07 (0.58) | −0.08 (0.50) | 0.25 (0.04) | 0.35 (0.01) | 0.04 (0.76) | 0.07 (0.59) | |
| 6 | −0.30 (0.02) | −0.03 (0.81) | −0.05 (0.71) | 0.11 (0.42) | 0.37 (0.02) | 0.16 (0.23) | 0.11 (0.39) | |
| IL−10 | 0 (A) | −0.14 (0.23) | −0.07 (0.55) | −0.22 (0.06) | 0.51 (<0.01) | 0.29 (0.02) | 0.23 (0.04) | 0.19 (0.10) |
| 0 | −0.23 (0.02) | −0.03 (0.78) | −0.25 (0.01) | 0.48 (<0.01) | 0.39 (<0.01) | 0.25 (0.01) | 0.20 (0.04) | |
| 1 | −0.10 (0.32) | −0.10 (0.29) | −0.30 (<0.01) | 0.34 (<0.01) | 0.25 (0.03) | 0.19 (0.05) | 0.21 (0.03) | |
| 2 | −0.12 (0.26) | −0.01 (0.95) | −0.17 (0.10) | 0.36 (<0.01) | 0.25 (0.04) | 0.30 (<0.01) | 0.17 (0.09) | |
| 3 | 0.08 (0.41) | −0.11 (0.28) | −0.10 (0.30) | 0.19 (0.05) | 0.14 (0.24) | 0.19 (0.05) | 0.05 (0.59) | |
| 4 | 0.02 (0.88) | −0.03 (0.77) | 0.14 (0.24) | 0.21 (0.08) | 0.19 (0.18) | 0.17 (0.13) | 0.11 (0.36) | |
| 5 | −0.03 (0.83) | −0.09 (0.45) | −0.13 (0.28) | 0.21 (0.08) | 0.25 (0.08) | 0.12 (0.32) | 0.15 (0.21) | |
| 6 | −0.11 (0.42) | 0.08 (0.56) | 0.05 (0.72) | 0.16 (0.23) | 0.28 (0.09) | 0.26 (0.05) | 0.08 (0.53) | |
| (IL−6*IL−8)/IL−10 index | 0 (A) | −0.17 (0.16) | 0.03 (0.78) | −0.02 (0.89) | 0.03 (0.81) | 0.003 (0.98) | 0.05 (0.68) | 0.03 (0.83) |
| 0 | −0.12 (0.25) | −0.04 (0.71) | 0.02 (0.81) | −0.03 (0.75) | −0.12 (0.31) | 0.01 (0.95) | −0.01 (0.96) | |
| 1 | 0.23 (0.02) | −0.15 (0.11) | 0.11 (0.25) | −0.15 (0.12) | −0.02 (0.85) | −0.19 (0.05) | −0.11 (0.24) | |
| 2 | 0.08 (0.45) | −0.07 (0.46) | 0.05 (0.63) | −0.08 (0.42) | 0.02 (0.87) | −0.26 (<0.01) | −0.14 (0.15) | |
| 3 | −0.05 (0.65) | −0.03 (0.75) | 0.09 (0.36) | −0.16 (0.10) | −0.05 (0.64) | −0.13 (0.18) | −0.01 (0.92) | |
| 4 | −0.004 (0.97) | −0.08 (0.49) | −0.13 (0.28) | −0.003 (0.98) | 0.05 (0.71) | −0.30 (<0.01) | −0.05 (0.65) | |
| 5 | −0.02 (0.86) | 0.06 (0.64) | 0.14 (0.25) | 0.24 (0.05) | 0.12 (0.40) | −0.11 (0.38) | −0.10 (0.40) | |
| 6 | −0.004 (0.98) | −0.18 (0.17) | −0.16 (0.24) | 0.16 (0.23) | 0.22 (0.19) | −0.10 (0.46) | 0.09 (0.48) | |
Analysis by Spearman ρ-correlation. A, admission; BE, base excess; DOL, day of Life; IL, interleukin; NRBCs, nucleated red blood cells; PI score, perinatal Insult score.
Bold represent p-values < 0.10.