Table 5.
Summary of mixed-model adjustments for indicators of HI severity, time of biomarker, sex, and neonatal infection status.
| β (95% CI) | p-value | Inter-p-value | |||
|---|---|---|---|---|---|
| Apgar 5 min | VEGF | TH | 0.052 (−0.029, 0.133) | 0.211 | 0.305 |
| Post-TH | 0.003 (−0.097, 0.103) | 0.951 | |||
| Tau | TH | −0.211 (−0.324, −0.098) | <0.001 | 0.537 | |
| Post-TH | −0.177 (−0.308, −0.047) | 0.008 | |||
| GFAP | TH | −0.273 (−0.418, −0.128) | <0.001 | 0.042 | |
| Post-TH | −0.179 (−0.336, −0.022) | 0.025 | |||
| IL-10 | TH | −0.101 (−0.205, 0.004) | 0.06 | 0.542 | |
| Post-TH | −0.063 (−0.191, 0.064) | 0.331 | |||
| Worse pH | VEGF | TH | 0.994 (0.003, 1.984) | 0.049 | 0.375 |
| Post-TH | 1.476 (0.284, 2.667) | 0.015 | |||
| Tau | TH | −1.344 (−2.670, −0.019) | 0.047 | 0.624 | |
| Post-TH | −1.036 (−2.541, 0.470) | 0.178 | |||
| GFAP | TH | −1.041 (−2.774, 0.692) | 0.239 | 0.623 | |
| Post-TH | −0.790 (−2.635, 1.054) | 0.401 | |||
| IL-10 | TH | −1.305 (−2.501, −0.109) | 0.032 | 0.296 | |
| Post-TH | −0.591 (−2.034, 0.852) | 0.422 | |||
| Base excess | VEGF | TH | 0.045 (0.019, 0.071) | 0.001 | 0.288 |
| Post-TH | 0.029 (−0.003, 0.061) | 0.08 | |||
| Tau | TH | −0.058 (−0.093, −0.024) | 0.001 | 0.811 | |
| Post-TH | −0.054 (−0.094, −0.015) | 0.007 | |||
| GFAP | TH | −0.062 (−0.110, −0.015) | 0.01 | 0.806 | |
| Post-TH | −0.059 (−0.109, −0.009) | 0.022 | |||
| IL-10 | TH | −0.058 (−0.093, −0.024) | 0.001 | 0.007 | |
| Post-TH | −0.006 (−0.047, 0.034) | 0.758 | |||
| NRBCs | VEGF | TH | −0.058 (−0.077, −0.038) | <0.001 | 0.305 |
| Post-TH | −0.048 (−0.068, −0.028) | <0.001 | |||
| Tau | TH | 0.022 (−0.007, 0.052) | 0.139 | 0.001 | |
| Post-TH | −0.013 (−0.043, 0.018) | 0.406 | |||
| GFAP | TH | −0.007 (−0.046, 0.032) | 0.738 | 0.312 | |
| Post-TH | −0.016 (−0.055, 0.024) | 0.433 | |||
| IL-10 | TH | 0.052 (0.026, 0.078) | <0.001 | 0.072 | |
| Post-TH | 0.029 (0.002, 0.056) | 0.033 | |||
| Lactate | VEGF | TH | −0.084 (−0.125, −0.042) | <0.001 | 0.447 |
| Post-TH | −0.066 (−0.117, −0.015) | 0.011 | |||
| Tau | TH | 0.143 (0.085, 0.200) | <0.001 | 0.138 | |
| Post-TH | 0.106 (0.041, 0.170) | 0.001 | |||
| GFAP | TH | 0.135 (0.058, 0.211) | 0.001 | 0.483 | |
| Post-TH | 0.150 (0.069, 0.231) | <0.001 | |||
| IL-10 | TH | 0.090 (0.035, 0.144) | 0.001 | 0.311 | |
| Post-TH | 0.060 (−0.005, 0.124) | 0.07 | |||
| Sarnat score | VEGF | TH | −0.246 (−0.536, 0.043) | 0.096 | 0.412 |
| Post-TH | −0.116 (−0.467, 0.235) | 0.517 | |||
| Tau | TH | 0.773 (0.407, 1.139) | <0.001 | 0.071 | |
| Post-TH | 1.088 (0.663, 1.513) | <0.001 | |||
| GFAP | TH | 0.744 (0.244, 1.243) | 0.004 | 0.014 | |
| Post-TH | 1.105 (0.574, 1.637) | <0.001 | |||
| IL-10 | TH | 0.577 (0.216, 0.939) | 0.002 | 0.657 | |
| Post-TH | 0.487 (0.051, 0.922) | 0.029 |
Mixed-model analysis with adjustments. GFAP, glial fibrillary acidic protein; NRBCs, nucleated red blood cells; PI score, perinatal Insult score; TH, therapeutic hypothermia; VEGF, vascular endothelial growth factor.
Bold represent p-values < 0.05.