Table 4.
AMR genes detected in 273 S. suis isolates in SC, NSC, NSP, and NSH groups.
| Drug Class | Number (%) of isolates | Genes/Proteins | ||||
|---|---|---|---|---|---|---|
|
Total (n = 273) |
SC (n = 47) |
NSC (n = 65) |
NSP (n = 71) |
NSH (n = 90) |
||
| Aminoglycosides | 111 (41) | 10 (21) | 23 (35) | 35 (49) | 43 (48) | ANT(6)-Ia, AAC(2′)-IIa, aad(6), APH(3′)-IIIa, AAC(6′)-Ie-APH(2″)-Ia, amrB, AAC(6′)-If, APH(3′)-IIb, APH(3′)-Ib, APH(2″)-IIIa |
| Carbapenems | 3 (<1) | 1 (1) | 1 (1) | 0 (0) | 1 (1) | PEDO-3,IND-4 |
| Diaminopyrimidines | 1 (<1) | 0 (0) | 1 (1) | 0 (0) | 0 (0) | dfrK |
| Glycopeptides | 1 (<1) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | vanTC |
| Lincosamides | 72 (26) | 7 (15) | 17 (26) | 15 (21) | 33 (37) | lnuB, lnuC |
| Mupirocin | 1 (<1) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | mupA |
| Nucleosides | 14 (<1) | 0 (0) | 1 (1) | 6 (8) | 7 (8) | SAT-4 |
| Penams | 4 (<1) | 0 (0) | 2 (2) | 0 (0) | 2 (2) | mecD, AER-1 |
| Phenicols | 2 (<1) | 0 (0) | 0 (0) | 0 (0) | 2 (2) | SS_cat |
| Tetracycline | 267 (98) | 47 (100) | 63 (97) | 70 (99) | 87 (97) | tetO, tet(45), tet(W/N/W), tetM, tet(L), tet(40) |
| MULTIDRUG RESISTANCES | ||||||
| Aminoglycoside, cephalosporin, cephamycin, penam | 2 (<1) | 1 (1) | 0 (0) | 0 (0) | 1 (1) | smeB |
| Carbapenem, cephalosporin, penam | 1 (<1) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | CGB-1 |
| Cephalosporin, cephamycin, penam | 1 (<1) | 1 (1) | 0 (0) | 0 (0) | 0 (0) | MOX-7 |
| Fluoroquinolone, aminoglycoside | 1 (<1) | 0 (0) | 0 (0) | 0 (0) | 1 (1) | ceoB |
| Macrolide, fluoroquinolone, rifamycin | 1 (<1) | 0 (0) | 0 (0) | 1 (1) | 0 (0) | efrA |
| Macrolide; lincosamide; streptogramin (MLS) | 245 (90) | 47 (100) | 54 (83) | 69 (97) | 75 (83) | ermB, ermG, ermT, ermK |
| MLS, tetracycline, oxazolidinone, phenicol, pleuromutilin | 57 (<1) | 4 (9) | 18 (28) | 14 (20) | 19 (21) | mel, IsaE |
SC = isolates from systemic sites in pigs with confirmed infections; NSC = isolates from non-systemic sites in pigs with confirmed infections; NSP = isolates from non-systemic sites in symptomatic pigs, which had no S. suis recovered from their systemic sites; NSH = isolates from non-systemic sites in healthy pigs.