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. 2021 Nov 2;9:736735. doi: 10.3389/fcell.2021.736735

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Copyright © 2021 Itoh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular matrix (ECM) and ECM receptors. Schematic representation of basement membrane and stromal ECM and ECM receptors. Selected ECM molecules are shown here including laminin, collagen IV (Coll-IV), collagen I (Coll-I), elastin, fibronectin (FN), tenascin C (TNC), proteoglycan (PG), and hyaluronic acid (HA). ECM receptors, including integrin, sydecans (SDC), discoidin domain receptors (DDRs), and CD44 are also shown. Integrins bind different matrix, including collagen, laminin, and FN. SDC binds TNC and FN through heparan sulfate (HS) chains. DDR1 binds to fibrillar collagens (Coll-I, Coll-II, Coll-III) and Coll-IV, while DDR2 binds to fibrillar collagens only. CD44 binds to HA.