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. 2021 Nov 2;12:775233. doi: 10.3389/fendo.2021.775233

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Copyright © 2021 Lin, Lass, Kong, Wang, Li, Huang and O’Byrne

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of optogenetic activation of ARC kisspeptin neurons on LH secretion in OVX estradiol capsule implanted Kiss-cre mice injected with estradiol benzoate. (A) Mean circulating levels of LH without optic stimulations of ARC kisspeptin neurons in OVX Kiss-cre mice implantation of estradiol capsule (E) and injection of estradiol benzoate (EB) and blood samples collected on the day of EB injection (OVX+E+EB, day1) (n = 4). (B) Mean circulating levels of LH secretion in response to 5 Hz blue-light stimulations of ARC kisspeptin neuron (14:30 - 16:30 h and 18:00 - 19:30 h) in Kiss-cre OVX+E+EB mice (n = 5). The values are presented as mean ± SEM. Lights off is at 19:00 h for all experiments, as indicated by the grey bar on the abscissa.