Table 3.
Univariate and multivariable Cox regression analysis for 6-month mortality.
| Clinical variables | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age | 1.04 (1.02-1.05) | <0.001 | 1.01 (0.99-1.03) | 0.603 |
| Female gender | 0.68 (0.43-1.09) | 0.109 | ||
| Weight | 1.00 (0.99-1.02) | 0.712 | ||
| Hypertension | 1.60 (1.00-2.55) | 0.049 | 0.86 (0.45-1.63) | 0.639 |
| Diabetes | 2.34 (1.35-4.06) | 0.002 | 1.41 (0.63-3.18) | 0.406 |
| Rheumatic heart disease | 2.01 (1.28-3.15) | 0.002 | 0.91 (0.46-1.81) | 0.790 |
| Congenital heart disease | 0.98 (0.64-1.50) | 0.916 | ||
| History of hemodialysis | 1.38 (0.19-9.93) | 0.747 | ||
| Prosthetic valve | 4.50 (2.73-7.43) | <0.001 | 2.87 (1.36-6.04) | 0.006 |
| NYHA class III or IV | 4.53 (2.98-6.88) | <0.001 | 3.33 (1.85-5.98) | <0.001 |
| WBC | 1.08 (1.04-1.11) | <0.001 | 1.02 (0.97-1.07) | 0.471 |
| Platelet <150×109/L | 2.55 (1.72-3.80) | <0.001 | 1.83 (1.10-3.05) | 0.020 |
| Anemia | 2.90 (1.59-5.31) | 0.001 | 2.15 (0.96-4.79) | 0.061 |
| Fasting blood-glucose | 1.30 (1.22-1.40) | <0.001 | 1.12 (1.02-1.23) | 0.022 |
| lgCRP | 3.75 (2.21-6.36) | <0.001 | 1.64 (0.86-3.14) | 0.135 |
| eGFR<60ml/min/1.73m2 | 3.90 (2.60-5.85) | <0.001 | 1.00 (0.97-1.03) | 0.841 |
| LVEF | 0.96 (0.94-0.98) | <0.001 | 2.41 (1.30-4.45) | 0.005 |
| Aortic valve vegetation | 2.80 (1.85-4.24) | <0.001 | 0.99 (0.56-1.74) | 0.968 |
| Mitral valve vegetation | 0.45 (0.30-0.67) | <0.001 | 0.21 (0.12-0.35) | <0.001 |
| Surgery treatment | 0.19 (0.13-0.29) | <0.001 | 2.87 (1.36-6.04) | 0.006 |
| UA, μmol/L | ||||
| 250-400 | 1 [Reference] | - | 1 [Reference] | - |
| <250 | 1.72 (0.97-3.05) | 0.062 | 2.23 (1.03-4.80) | 0.041 |
| >400 | 3.01 (1.86-4.90) | <0.001 | 3.54 (1.77-7.07) | <0.001 |
NYHA, New York Heart Association; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction.