Figure 1.

Infusion of omentin-1 enhanced plaque stability in ApoE^−/− mice. (A) Representative images of aortic root lesion sections of ApoE^−/− mice stained by hematoxylin and Masson's trichrome. (B) Graph shows the formation of necrotic cores. The formation of necrotic cores (pointed out by dot line) was assessed by calculating the proportion of necrosis area in the plaque (n₁ = 8, n_2,3,4 = 10). (C) Graph shows the collagen content of atherosclerosis (AS) plaque. Collagen content was expressed in the proportion of collagen fiber (blue) in the plaque area (n₁ = 8, n_2,3,4 = 10). (D) Graph shows the size of the AS lesion in each group. No significant difference was found between the experimental groups and control groups (n₁ = 8, n_2,3,4 = 10). (E) Representative images of the aortic root sections of mice stained by oil red O. (F) Graph show the lipid content (red) in the plaque area. The lipid content was expressed in the proportion of oil red positive area in plaque area (n₁ = 8, n_2,3,4 = 10). All data in this figure were presented as mean ± SEM [n.s., non-significant; n₁, the number of subjects in Before Surgery group; n₂, the number of subjects in normal saline (NS) infusion group; n₃, the number of subjects in group infused with omentin-1 (1 μg/kg/h); n₄, the number of subjects in group infused with omentin-1 (5 μg/kg/h)].