Table 3.
Before surgery | NS infusion |
Omentin-1
(1 μg/kg/h) |
Omentin-1
(5 μg/kg/h) |
|
---|---|---|---|---|
Male (%) | 100 | 100 | 100 | 100 |
Age (weeks) | 20 | 23 | 23 | 23 |
Body weight (g) | 29.1 ± 0.7 | 30 ± 0.64 | 29.4 ± 0.65 | 30.4 ± 0.8 |
Systolic BP (mmHg) | 102.4 ± 1.4 | 103.7 ± 1.3 | 103 ± 1.7 | 104.1 ± 1.5 |
Diastolic BP (mmHg) | 78.3 ± 1.8 | 81 ± 1.9 | 78.1 ± 2.1 | 79.2 ± 2.2 |
Glucose (mg/dl) | 192.1 ± 8.7 | 207.1 ± 5.2 | 199.7 ± 4.8 | 196.2 ± 5.2 |
Triglyceride (mg/dl) | 66.7 ± 2.1 | 65.4 ± 2.0 | 64.3 ± 1.8 | 64.0 ± 2.0 |
Total cholesterol (mg/dl) | 1713 ± 41.2 | 1723 ± 38.0 | 1655 ± 32.3 | 1594 ± 44.7 |
LDL-C (mg/dl) | 274 ± 8.5 | 251.7 ± 8.5 | 248.4 ± 9.0 | 238.7 ± 9.9 |
HDL-C (mg/dl) | 36.9 ± 0.7 | 36.5 ± 0.6 | 36.6 ± 0.6 | 36.4 ± 0.7 |
Human omentin-1 (ng/ml) | 1.19 ± 0.03 | 1.2 ± 0.05 | 59.82 ± 4.3*,† | 433 ± 19.1**,‡,¶ |
n | 10 | 16 | 16 | 16 |
Baseline characteristics of ApoE−/− mouse was recorded. And the blood samples of them were collected and subjected to biochemical analysis. Before surgery represents the group without ALZET minipump implantation. NS infusion represents the group infused with normal sodium solution (vehicle). Omentin-1 represents the group infused with omentin-1-containing solution [
P < 0.05,
P < 0.0001 vs. the group without ALZET minipump implantation (Before surgery);
P < 0.05,
P < 0.0001 vs. the group infused with normal sodium solution (NS infusion);
P < 0.0001 vs. the group infused with low concentration of omentin-1 solution (omentin-1 1 μg/kg/h)].