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. 2021 Nov 2;12:762160. doi: 10.3389/fgene.2021.762160

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Copyright © 2021 Sun, Li, Yao, Liu, Yang, Ma and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of frequently mutated genes and TMB in COAD. (A) Waterfall plot shows the frequently mutated genes in COAD from TCGA database. The left panel shows mutation frequency, and genes are ordered by their mutation frequencies. The right panel presents different mutation types. (B) Waterfall plot displaying the frequently mutated genes in COAD from the ICGC cohort. The left panel shows the genes ordered by their mutation frequencies. The right panel presents different mutation types. (C) Venn diagram shows 22 frequently mutated genes covered by both the TCGA and ICGC cohorts. (D) 21 genes with high mutation frequency are associated with a higher TMB. ***p < 0.001, **p < 0.01, *p < 0.05, ns has no statistical difference.