Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 2;12:748568. doi: 10.3389/fphar.2021.748568

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Fan, Yao, Yang, Han, Zhang, Wang, Li, Xu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Putative mechanism for the therapeutic effect of SLT on brain ischemia. Occlusions in the cerebral arteries induce a drastic elevation in ROS contents; the excess ROS severely disrupts the brain blood barriers, leading to serious leakages from the blood vessels and brain edema, finally resulting in an infarction of large volume. SLT dramatically releases Nrf2 detained in the cytoplasm and promotes its nucleus translocation, thus priming the downstream transcriptions and increasing the contents of HO-1, SOD, and GSH, which then lead to massive elimination of ROS, cutting off the injury cascade and finally rescuing the brain from ischemia.