Table 3.
Correlation Analysis of DLEU2 Expression with Molecular Markers of Immune Cells
Immune Cell Type | Molecular Markers | KIRC | LIHC | ||||||
---|---|---|---|---|---|---|---|---|---|
None | Purity | None | Purity | ||||||
cor | p | cor | p | cor | p | cor | p | ||
B cell | CD19 | 0.176 | **** | 0.151 | ** | 0.195 | *** | 0.23 | **** |
CD79A | 0.083 | 0.054 | 0.066 | 0.156 | 0.193 | *** | 0.273 | **** | |
Dendritic cell | ITGAX | 0.321 | **** | 0.303 | **** | 0.327 | **** | 0.406 | **** |
NRP1 | 0.205 | **** | 0.196 | **** | 0.261 | **** | 0.271 | **** | |
CD1C | 0.117 | ** | 0.118 | * | 0.188 | *** | 0.238 | **** | |
HLA−DPA1 | 0.209 | **** | 0.206 | **** | 0.146 | ** | 0.21 | **** | |
HLA−DRA | 0.187 | **** | 0.197 | **** | 0.137 | ** | 0.196 | *** | |
HLA−DQB1 | 0.152 | *** | 0.132 | ** | 0.137 | ** | 0.203 | *** | |
HLA−DPB1 | 0.145 | *** | 0.136 | ** | 0.114 | * | 0.173 | ** | |
Monocyte | CSF1R | 0.166 | *** | 0.134 | ** | 0.14 | ** | 0.219 | **** |
CD86 | 0.211 | **** | 0.199 | **** | 0.267 | **** | 0.365 | **** | |
Macrophage | PTGS2 | 0.159 | *** | 0.112 | * | 0.113 | * | 0.179 | *** |
IRF5 | 0.32 | **** | 0.332 | **** | 0.355 | **** | 0.349 | **** | |
VSIG4 | 0.133 | ** | 0.109 | * | 0.058 | 0.264 | 0.119 | * | |
MS4A4A | 0.223 | **** | 0.221 | **** | 0.116 | * | 0.188 | *** | |
CD163 | 0.186 | **** | 0.181 | **** | 0.096 | * | 0.151 | ** | |
Natural killer cell | KIR3DL3 | 0.064 | 0.139 | 0.042 | 0.369 | 0.119 | * | 0.103 | 0.056 |
KIR3DL2 | 0.073 | 0.090 | 0.069 | 0.142 | 0.116 | * | 0.153 | ** | |
KIR3DL1 | 0.08 | 0.066 | 0.08 | 0.086 | 0.076 | 0.143 | 0.08 | 0.138 | |
KIR2DS4 | 0.108 | * | 0.114 | * | 0.162 | ** | 0.14 | ** | |
KIR2DL4 | 0.186 | **** | 0.188 | **** | 0.221 | **** | 0.242 | **** | |
KIR2DL3 | 0.079 | 0.070 | 0.073 | 0.117 | 0.133 | * | 0.153 | ** | |
KIR2DL1 | 0.1 | * | 0.089 | * | −0.016 | 0.76 | −0.045 | 0.407 | |
Neutrophils | CCR7 | 0.145 | *** | 0.125 | ** | 0.165 | ** | 0.243 | **** |
ITGAM | 0.192 | **** | 0.179 | *** | 0.197 | *** | 0.245 | **** | |
CEACAM8 | 0.135 | ** | 0.133 | ** | 0.09 | 0.084 | 0.101 | 0.061 | |
T cell (general) | CD3D | 0.242 | **** | 0.222 | **** | 0.257 | **** | 0.344 | **** |
CD3E | 0.254 | **** | 0.231 | **** | 0.228 | **** | 0.335 | **** | |
CD2 | 0.271 | **** | 0.254 | **** | 0.228 | **** | 0.332 | **** | |
Treg | TGFB1 | 0.123 | ** | 0.105 | * | 0.201 | **** | 0.262 | **** |
FOXP3 | 0.193 | **** | 0.151 | ** | 0.247 | **** | 0.268 | **** | |
STAT5B | 0.193 | **** | 0.209 | **** | 0.249 | **** | 0.224 | **** | |
CCR8 | 0.261 | **** | 0.253 | **** | 0.364 | **** | 0.417 | **** | |
T cell exhaustion | CTLA4 | 0.407 | **** | 0.387 | **** | 0.3 | **** | 0.384 | **** |
LAG3 | 0.28 | **** | 0.258 | **** | 0.333 | **** | 0.371 | **** | |
HAVCR2 | 0.1 | * | 0.101 | * | 0.252 | **** | 0.352 | **** | |
GZMB | 0.237 | **** | 0.222 | **** | 0.157 | ** | 0.194 | *** | |
PDCD1 | 0.264 | **** | 0.259 | **** | 0.323 | **** | 0.389 | **** | |
CD8+T cell | CD8A | 0.275 | **** | 0.278 | **** | 0.228 | **** | 0.157 | ** |
CD8B | 0.228 | **** | 0.229 | **** | 0.181 | *** | 0.288 | **** | |
Th1 | TBX21 | 0.313 | **** | 0.308 | **** | 0.2 | *** | 0.365 | **** |
STAT4 | 0.435 | **** | 0.424 | **** | 0.284 | **** | 0.293 | **** | |
STAT1 | 0.343 | **** | 0.351 | **** | 0.373 | **** | 0.143 | ** | |
IFNG | 0.317 | **** | 0.316 | **** | 0.243 | **** | 0.305 | **** | |
IL13 | 0.276 | **** | 0.269 | **** | 0.135 | ** | 0.257 | **** | |
Th2 | GATA3 | 0.08 | 0.065 | 0.046 | 0.328 | 0.242 | **** | 0.27 | **** |
STAT6 | 0.216 | **** | 0.235 | **** | 0.21 | **** | 0.332 | **** | |
STAT54 | 0.196 | **** | 0.181 | **** | 0.284 | **** | 0.393 | **** | |
Th17 | STAT3 | 0.221 | **** | 0.219 | **** | 0.058 | 0.268 | 0.305 | **** |
IL17A | 0.046 | 0.285 | 0.042 | 0.368 | 0.177 | *** | 0.142 | ** | |
TAM | CCL2 | 0.214 | **** | 0.178 | *** | 0.099 | 0.057 | 0.351 | **** |
IL10 | 0.234 | **** | 0.222 | **** | 0.224 | **** | 0.177 | *** | |
CD68 | 0.024 | 0.574 | 0.036 | 0.443 | 0.166 | ** | 0.317 | **** | |
Tfh | BCL6 | 0.28 | **** | 0.268 | **** | 0.292 | **** | 0.056 | 0.297 |
IL21 | 0.11 | * | 0.106 | * | 0.123 | * | 0.175 | ** |
Notes: *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.
Abbreviations: KIRC, Kidney renal clear cell carcinoma; LIHC, Liver hepatocellular carcinoma.