Table 1. Demographic and clinical characteristics of the study population according to the presence or absence of MIAC, IAI, and microbial-associated IAI in women with preterm premature rupture of membranes.
| Variables | MIAC | P value | IAI | P value | Microbial-associated IAI | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| Positive (n = 60) | Negative (n = 108) | Positive (n = 70) | Negative (n = 98) | Positive (n = 50) | Negative (n = 118) | ||||
| Maternal age, yr | 32.0 ± 3.7 | 31.0 ± 3.9 | 0.088 | 31.7 ± 3.6 | 31.1 ± 4.0 | 0.349 | 31.9 ± 3.8 | 31.2 ± 3.9 | 0.269 |
| Nulliparity | 40.0 (24/60) | 52.8 (57/108) | 0.113 | 37.1 (26/70) | 56.1 (55/98) | 0.016 | 36.0 (18/50) | 53.4 (63/118) | 0.040 |
| Gestational age at sampling, wk | 29.7 ± 2.7 | 30.7 ± 2.6 | 0.010 | 29.4 ± 2.7 | 31.1 ± 2.4 | < 0.001 | 29.5 ± 2.6 | 30.7 ± 2.6 | 0.002 |
| Gestational age at delivery, wk | 30.9 ± 2.4 | 33.1 ± 2.6 | < 0.001 | 31.7 ± 2.5 | 33.4 ± 2.3 | < 0.001 | 30.6 ± 2.3 | 33.0 ± 2.5 | < 0.001 |
| Serum CRP, mg/dL | 1.2 ± 1.5 | 0.7 ± 1.1 | 0.019 | 1.4 ± 1.7 | 0.5 ± 0.6 | < 0.001 | 1.4 ± 1.6 | 0.6 ± 1.0 | 0.003 |
| Use of tocolytic agents | 63.3 (38/60) | 57.4 (62/108) | 0.455 | 67.1 (47/70) | 54.1 (53/98) | 0.090 | 70.0 (35/50) | 55.1 (65/118) | 0.073 |
| Use of antibiotics | 98.3 (59/60) | 93.5 (101/108) | 0.261 | 95.7 (67/70) | 94.9 (93/98) | 1.000 | 98.0 (49/50) | 94.1 (111/118) | 0.438 |
| Use of antenatal corticosteroids | 93.3 (56/60) | 89.8 (97/108) | 0.577 | 92.9 (65/70) | 89.8 (88/98) | 0.590 | 92.0 (46/50) | 90.7 (107/118) | 1.000 |
| Clinical chorioamnionitis | 11.7 (7/60) | 8.3 (9/108) | 0.482 | 10.0 (7/70) | 9.2 (9/98) | 0.859 | 12.0 (6/50) | 8.5 (10/118) | 0.478 |
| Histological chorioamnionitisa | 72.7 (40/55) | 40.0 (38/95) | < 0.001 | 73.4 (47/64) | 36.0 (31/86) | < 0.001 | 76.1 (35/46) | 41.3 (43/104) | < 0.001 |
Data are given as mean ± standard deviation or % (n/N).
MIAC = microbial invasion of the amniotic cavity, IAI = intra-amniotic inflammation, CRP = C-reactive protein.
aData for the histologic evaluation of the placenta were only available in 150 of the 168 women because in 15 cases, delivery took place at another institution and in 3 cases, histologic evaluation of the placenta was not performed because of our institutional policy that only the placentas in cases of preterm delivery are to be sent for histopathologic examination or because of missing data for the histological chorioamnionitis.
Significant findings (P < 0.05) are indicated in bold fonts.