Table 2. Various proteins levels in plasma and amniotic fluid of the study population according to the presence or absence of MIAC, IAI, and microbial-associated IAI in women with preterm premature rupture of membranes.

Variables	MIAC		P value	IAI		P value	Microbial-associated IAI		P value
	Positive (n = 60)	Negative (n = 108)		Positive (n = 70)	Negative (n = 98)		Positive (n = 50)	Negative (n = 118)
Plasma LBP, µg/mL	7.11 ± 4.31	5.41 ± 3.10	0.006	7.18 ± 4.51	5.19 ± 2.63	0.001	7.33 ± 4.52	5.46 ± 3.08	0.004
AF LBP, µg/mL	0.38 ± 0.48	0.21 ± 0.21	0.006	0.42 ± 0.46	0.17 ± 0.15	< 0.001	0.44 ± 0.51	0.21 ± 0.21	< 0.001
Plasma PTX3, ng/mL	7.78 ± 5.16	8.99 ± 8.57	0.426	8.56 ± 7.01	8.56 ± 7.92	0.452	7.62 ± 5.30	8.96 ± 8.29	0.976
AF PTX3, ng/mL	19.31 ± 18.53	2.81 ± 8.26	< 0.001	19.18 ± 18.38	1.19 ± 3.91	< 0.001	22.39 ± 18.30	2.95 ± 8.53	< 0.001
Plasma resistin, ng/mL	79.20 ± 133.25	53.11 ± 48.65	0.142	62.81 ± 53.09	61.98 ± 107.75	0.150	63.46 ± 55.47	61.84 ± 99.92	0.246
AF resistin, ng/mL	337.66 ± 359.11	70.21 ± 153.41	< 0.001	349.14 ± 355.33	34.47 ± 34.96	< 0.001	394.42 ± 367.45	69.30 ± 148.65	< 0.001
Plasma IGFBP-3, ng/mL	813.80 ± 130.71	849.68 ± 158.40	0.067	789.45 ± 126.29	870.74 ± 156.38	< 0.001	817.57 ± 109.02	845.04 ± 163.65	0.101
AF IGFBP-3, ng/mL	688.44 ± 358.31	771.72 ± 300.34	0.115	695.76 ± 364.27	775.10 ± 288.59	0.130	655.70 ± 366.43	778.31 ± 298.09	0.027
AF IL-8, ng/mL	19.76 ± 37.35	2.22 ± 5.56	< 0.001	19.23 ± 34.74	0.79 ± 1.17	< 0.001	23.48 ± 40.02	2.16 ± 5.35	< 0.001

Data are given as mean ± standard deviation.

MIAC = microbial invasion of the amniotic cavity, IAI = intra-amniotic inflammation, LBP = lipopolysaccharide binding protein, AF = amniotic fluid, PTX3 = pentraxin 3, IGFBP = insulin-like growth factor-binding protein, IL = interleukin.

Significant findings (P < 0.05) are indicated in bold fonts.