Table 2. Comparison between the EIM-positive and -negative groups in CD patients.
| Variables | EIM-positive group (n = 34) | EIM-negative group (n = 103) | P | |
|---|---|---|---|---|
| Male sex | 21 (61.8) | 77 (74.8) | 0.216 | |
| Age at diagnosis, yr | 13.9 (11.7–16.3) | 14.1 (12.6–15.1) | 0.929 | |
| Age at maximum follow-up, yr | 17.8 (15.1–20.3) | 18.0 (15.6–20.3) | 0.325 | |
| Paris classification age | 0.092 | |||
| A1a | 7 (6.8) | 6 (17.6) | ||
| A1b | 89 (86.4) | 24 (70.6) | ||
| A2 | 7 (6.8) | 4 (11.8) | ||
| Lower GI tract location | 0.523 | |||
| L1 | 12 (11.7) | 2 (5.9) | ||
| L2 | 6 (5.8) | 3 (8.8) | ||
| L3 | 85 (82.5) | 29 (85.3) | ||
| Upper GI tract location | 0.407 | |||
| No involvement | 40 (38.8) | 11 (29.4) | ||
| L4a | 20 (19.4) | 10 (29.4) | ||
| L4b | 18 (17.5) | 8 (23.5) | ||
| L4a+b | 25 (24.3) | 7 (20.6) | ||
| GI tract behavior | 0.814 | |||
| B1 | 87 (84.5) | 27 (79.4) | ||
| B2 | 13 (12.6) | 6 (17.6) | ||
| B3/B2B3 | 3 (2.9) | 1 (2.9) | ||
| Perianal modifiers | 43 (41.7) | 18 (52.9) | 0.347 | |
| Growth retardation | 20 (19.4) | 12 (35.5) | 0.125 | |
| PCDAI at diagnosis | 42.5 (17.5–50) | 42.5 (35.0–47.5) | 0.547 | |
| CRP at diagnosis, mg/dL | 3.8 (1.9–6.6) | 3.2 (0.3–6.3) | 0.186 | |
| ESR at diagnosis, mm/hr | 44 (28–65) | 39.5 (20–74) | 0.405 | |
| FC at diagnosis, mg/kg | 526 (248–1,000) | 350 (66–684) | 0.131 | |
Data are expressed as median (interquartile range) for continuous variables that did not show normal distribution, unless otherwise indicated.
EIM = extraintestinal manifestation, CD = Crohn's disease, GI = gastrointestinal, A1a = 0–9 years, A1b = 10–16 years, A2 = ≤ 17 years, L1 = distal 1/3 ileum ± limited cecal disease, L2 = colonic disease, L3 = ileocolonic disease, L4a = upper disease proximal to ligament of Treitz, L4b = upper disease distal to the ligament of Treitz and proximal to the distal 1/3 ileum, L4ab = upper disease involvement in both L4a and L4b, B1 = nonstricturing nonpenetrating behavior, B2 = stricturing behavior, B3 = penetrating behavior, B2B3 = both B2 and B3, PCDAI = Pediatric Crohn's Disease Activity Index, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, FC = fecal calprotectin.