Table 3. Comparison between the EIM-positive and -negative groups in UC patients.
| Variables | EIM-positive group (n = 8) | EIM-negative group (n = 27) | P | |
|---|---|---|---|---|
| Male sex | 21 (61.8) | 77 (74.8) | 0.216 | |
| Age at diagnosis, yr | 13.9 (11.7–16.3) | 14.1 (12.6–15.1) | 0.929 | |
| Age at maximum follow-up, yr | 17.8 (15.1–20.3) | 18.0 (15.6–20.3) | 0.325 | |
| UC extent | 0.678 | |||
| E1 | 1 (3.7) | 0 (0.0) | ||
| E2 | 5 (18.5) | 0 (0.0) | ||
| E3 | 4 (14.8) | 2 (25.0) | ||
| E4 | 17 (63.0) | 6 (75.0) | ||
| UC severity | 0.011 | |||
| S0 | 2 (25.0) | 21 (77.8) | ||
| S1 | 6 (75.0) | 6 (22.2) | ||
| PUCAI at diagnosis | 53.8 ± 18.1 | 41.7 ± 17.5 | 0.098 | |
| CRP at diagnosis, mg/dL | 0.5 (0.3–3.0) | 0.3 (0.1–0.8) | 0.478 | |
| ESR at diagnosis, mm/hr | 36 ± 22 | 21 ± 16 | 0.043 | |
| FC at diagnosis, mg/kg | 1,000 ± 62 | 949 ± 818 | 0.876 | |
Data are expressed as means ± standard deviation for continuous variables that showed normal distribution, and median (interquartile range) for continuous variables that did not show normal distribution, unless otherwise indicated.
EIM = extraintestinal manifestation, UC = ulcerative colitis, E1 = ulcerative proctitis, E2 = left-sided UC (distal to splenic flexure), E3 = extensive (hepatic flexure distally), E4 = pancolitis (proximal to hepatic flexure), S0 = never severe (PUCAI < 65), S1 = ever severe (PUCAI ≥ 65), PUCAI = Pediatric Ulcerative Colitis Activity Index, CRP = C-reactive protein, ESR = erythrocyte sedimentation rate, FC = fecal calprotectin.